Serine, cysteine and threonine proteases are involved in covalent catalysis. The anti-tumour effects of the prodrugs n-l-leucyl-doxorubicin and vinblastine-isoleucinate in human ovarian cancer xenografts.
The nucleophile of the catalytic site is part of the specified amino acid.
The presence of protective proteases can predict good clinical prognosis but their absence can indicate the need for different treatments.
This approach has been show to work in lentiviral-mediated neprilysin gene transfer to block prostate cancer growth . Urinary kallikrein excretion in essential and mineralocorticoid hypertension.
Third, an indirect approach is to hamper protease inhibitors to reduce protective (anti-tumor) proteases.
No doubt the fleas of the Florida Keys are well fed in that certain others including Supa-stah and her sistah have been afflicted.
Even stranger is that the insect bites did not appear until a week later.